NexCore

Zero-dependency error handling for NexVigilant Core ecosystem

The 16 irreducible Lex Primitiva symbols with mathematical constants grounding

Sovereign DateTime engine — UTC timestamps, calendar dates, durations with zero external dependencies

Zero-dependency UUID implementation for NexVigilant Core ecosystem

Zero-dependency filesystem utilities (dirs, walkdir, glob, temp, expand) for NexCore ecosystem

T1/T2-P bedrock types: Confidence, Measured, Tier, Correction

Pharmaceutical company domain models — products, pipelines, safety profiles, and competitive analysis

Universal computational primitives (Chemistry, Physics, Math) for the NexVigilant Core ecosystem

Mathematics primitives: sets, relations, proofs, bounds

Drug entity domain models — identity, classification, indications, safety signals, and label status

Zero-dependency codec library (hex, base64, percent-encoding) for NexCore ecosystem

Disease domain models — epidemiology, treatment landscape, safety burden, and unmet needs

Pharmacovigilance signal detection core: PRR, ROR, IC, EBGM, Chi², causality, FAERS, risk analytics

NexVigilant Core: The Vigilance Kernel - Theory of Vigilance, Guardian-AV, and consolidated domain modules

Typed event signaling system based on immune cytokine patterns

Three-node flywheel bridge with five autonomous loops for self-reinforcing feedback

PRPaaS core domain types — TenantContext, type-safe IDs, tenant isolation primitives

Generic edit distance framework: pluggable operations, cost models, and solvers

Zero-dependency cryptographic hashing (SHA-256, HMAC-SHA256) for NexCore ecosystem

Platform Abstraction Layer — hardware-agnostic traits for NexCore OS

Grounded signal types and methods for the NexVigilant Core ecosystem

STEM primitives: Science, Technology, Engineering, Mathematics as Rust traits

CART-inspired decision tree engine: trainable binary splitting with pluggable criteria

Linux platform implementation for NexCore PAL — sysfs, evdev, DRM backends

Browser automation foundation for Vigil/Guardian ecosystem

Sovereign columnar DataFrame engine — zero-unsafe, zero-external-dependency replacement for polars

Endocrine system for .claude - persistent state modulators affecting behavior across sessions

Pure Rust molecular core: SMILES parser, molecular graph, descriptors, fingerprints

Schema contract registry with drift detection — translates inferred schemas into enforceable contracts

Theory of Vigilance: grounded primitives and Curry-Howard proof verification

Reverse transcriptase engine — bidirectional data-to-schema pipeline with fidelity verification and violation synthesis

Molecular primitives for Prima language - SMILES parsing, 3D geometry, reaction modeling

Antigravity-style brain system for Claude Code - working memory, artifact versioning, and content-addressable code tracking

Token-as-energy system modeled on ATP/ADP biochemistry (Atkinson Energy Charge)

Guardian homeostasis engine — SENSE→COMPARE→ACT control loop with threat sensing

Insight engine: pattern detection, novelty recognition, connection mapping, and observation compression grounded in Lex Primitiva T1 primitives

Mathematically rigorous crate and workspace quality measurement: information theory, graph theory, statistics

NexCore OS — Operating system core runtime with STOS-based boot sequence

Chemistry-inspired semantic transformation engine — provable regulatory terminology equivalence

Skill Execution Engine - Real execution of Claude Code skills via shell, binary, or library invocation

Universal Theory of State — domain-agnostic state machine foundations

Complex number arithmetic for mathematical computing

Typed transport for PV rails — separates cargo (domain payload) from freight (conveyance)

Circulatory system for data transport — Heart(pump/collect/distribute) → Vessels(route) → Blood(carry/detect/repair)

5-level security classification with tiered enforcement for NexVigilant

NexCore Compositor — display server for watch, phone, and desktop

Digestive system for data processing — sequential pipeline: Mouth(parse) → Stomach(decompose) → Intestine(triage) → Liver(transform)

Shared types and math for the Homeostasis Machine — biological self-regulation for software

Shared hormone type definitions used across stem-foundation and bio-molecular holds

Antipattern immunity system - self-healing code through learned antibodies

Integumentary system for boundary protection — Epidermis(auth/validate) → Dermis(sensors) → Interface(display/respond)

Lymphatic system for overflow drainage — Output styles(lymph drainage) + Notification hooks(lymph nodes) + Thymic selection(self vs non-self) + Passive overflow

Muscular system for tool execution — Skeletal(voluntary tools) + Smooth(autonomic tools) + Cardiac(main event loop), Size Principle, antagonistic pairs

Nervous system for event routing — Reflex arcs(hook dispatch) + Myelination(hot path caching) + Sensory integration(context assembly) + Motor coordination(tool chains)

Pharmacovigilance Operating System — 15-layer T3 platform with T1 primitive grounding

Reproductive system for CI/CD — Gametes(build artifacts) + Fertilization(merge/test) + Trimester gates(validation phases) + Differentiation(env adaptation) + Birth(deployment)

Respiratory system for I/O management — Intake(inhale/filter) → Exchange(extract/exhale) → Rhythm(regulate)

NexCore Shell — device launcher and home screen for watch, phone, and desktop

Universal Theory of Signals — domain-agnostic signal detection foundations

Skeletal system for structural integrity — CLAUDE.md (skull), project structure (limbs), interfaces (joints), Wolff's Law (adaptive reinforcement)

State Operating System — 15-layer runtime for state machine orchestration

Amplitude growth learning model with quantum-grounded mathematics

Urinary system for filtration — Nephron(log filtering) + Reabsorption(metric reclaim) + Excretion(waste disposal) + Retention policies(tubular reabsorption)

Classical number theory: primes, arithmetic functions, factorization

NexCore Audio — OS audio subsystem with PCM formats, mixing, and streaming

Compound resolution via PubChem/ChEMBL with local SQLite cache

Local LLM inference engine using HuggingFace Candle with NexCloud fine-tuning

Persistent SQLite storage for NexCore Brain working memory

DNA-based computation: nucleotide types, data storage, biological operations, a 64-instruction Codon VM, assembler, and disassembler. Zero external dependencies.

Domain primitive extraction: tier taxonomy (T1/T2-P/T2-C/T3), dependency graphs, and cross-domain transfer confidence

Stream FAERS quarterly ASCII files and generate drug-event contingency tables for signal detection

FDA Guidance Documents: search, retrieval, and refresh for 2,794+ FDA guidance documents

Focused FHIR R4 types for pharmacovigilance — AdverseEvent, Patient, Medication, and PV-relevant resources

Evolved forge strategy parameters discovered by genetic algorithm training

Typed artifact schemas for The Foundry assembly line architecture

Harm Classification Taxonomy (ToV §9): 8 harm types A-H, conservation law connections, manifestation levels

Virtual laboratory for word/concept experiments using Lex Primitiva molecular weight and T1 primitive decomposition

NexVigilant Core Labs: Experimental and non-core domain modules (Quiz, Betting, Academy)

Runtime mesh networking with discovery, gossip, and resilience — grounded to 14/16 T1 primitives

Phase I/II metabolite and degradant prediction engine

Generalized OpenFDA REST API client covering all endpoints with rate limiting, caching, and V33 contingency

Perplexity AI Sonar API client for search-grounded research

Adversarial test fixture generator — produces schema mutations for drift detection testing

Preemptive Pharmacovigilance: three-tier signal detection (Reactive, Predictive, Preemptive) with thermodynamic feasibility and competitive inhibition intervention model

Pharmacovigilance Domain-Specific Language with custom bytecode compiler

Quantitative Benefit-Risk: computable, confidence-bounded benefit-risk assessment from contingency data

Rule-based toxicity prediction models with applicability domain

Skill registry, routing, validation, taxonomy, and code generation engine

Social media API clients for value signal detection

Shared social media types extracted from nexcore-social for cross-hold consumption

ICH M7 structural alert library with substructure matching

NexVigilant Terminal — multi-tenant, AI-augmented terminal sessions

Bayesian trust engine: Beta(alpha, beta) scoring, asymmetric evidence weighting, temporal decay, multi-dimensional trust (Mayer et al.), and network transitivity

Economic value signal detection using PV algorithms

Zero-dependency local encrypted secret manager using PBKDF2 + AES-256-GCM via ring

Always-on vigilance orchestrator - voice, webhooks, scheduler integration

Riemann Zeta function and L-function computation

Academic course classification primitives for Prima

Prima Universal Code Generator - T1 primitives to target languages

Thin re-export wrapper for nexcore-signal-pipeline — the canonical signal detection pipeline

Extract structured knowledge from NexCore Rust source into IR for Academy and Observatory

AI text detector via statistical fingerprints — Zipf deviation, entropy uniformity, burstiness dampening, perplexity consistency, TTR anomaly

Parser and validator for .true formal axiom files

Detection/counter-detection matrix formalization for multi-spectral awareness resistance

Topological DAG publisher for nexcore crates — scans Cargo.toml files, builds dependency graph, and publishes in correct order

Forward-only compound discovery loop. Assess state, reject regression, search for novelty, arrive at new state. Based on T1 primitive decomposition of Walt Disney's curiosity doctrine.

GROUNDED: Giving Reasoning Observable, Unified, Nested, Developmental, Evidence-based Dynamics

Rust-native cloud platform: 35-type taxonomy + process supervisor + reverse proxy

T1 fold/aggregate/recursive combinators — fills Σ, ρ, κ primitive gaps

Algorithmic vigilance: ICSR deduplication, signal triage with decay, and federated persistence

Structural anatomy analysis for Rust workspaces — dependency graph metrics, layer validation, Chomsky classification, and criticality scoring

Adaptive immune layer for targeted threat recognition and neutralization. Complements nexcore-immunity (innate) with learned epitope-paratope binding.

Autonomous State Machine — runtime state machines with guarded transitions, autonomous ticking, and persistence

Cargo build coordination for multi-agent environments

Full-stack build orchestrator with CI/CD pipeline, live dashboard, and CLI

Caesura detection — finds structural seams where coding style, architecture, or dependencies shift abruptly

Cardiovascular data transport system — heart pump, vessel hierarchy, blood components, and pressure regulation

Consultants' Client Care Process — 5-phase PV consulting workflow engine

Capability Compound Interest Machine — sovereign development acceleration modeled as financial instrument

Claude Care Process pharmacokinetic engine — 5-phase FSM with PK math

Chemivigilance pipeline orchestrator generating SafetyBrief with min-3 limitations

Typed cognitive engine — transformer algorithm as strict Rust. Attention, transformation, generation, and self-measurement.

Combinatorial algorithms from Dudeney cross-domain transfer: Catalan numbers, derangements, cycle decomposition, Josephus problem, linear extensions

The Full Compilation Space — 7-axis framework for modeling code transformations

Regulatory compliance engine: SAM.gov integration, OSCAL-inspired DSL, FDA/ICH/CIOMS controls

Type-safe configuration consolidation for NexVigilant Core ecosystem

Clinical Trial Validation Paradigm (CTVP) - Software validation using pharmaceutical methodology

Feedback-controlled kinetic governance — ∂(→(ν, ς, ρ)) typed as Rust

Latin-inspired architectural primitives — declension classes, component cases, inflected tools, pro-drop inference, and agreement checking

Downloads Intelligence Scanner - classifies files by NexVigilant Core relevance

Adalimumab (Humira) — drug safety model for AbbVie

Apixaban (Eliquis) — drug safety model for Pfizer/Bristol-Myers Squibb

Dapagliflozin (Farxiga) — drug safety model for AstraZeneca

Donanemab (Kisunla) — drug safety model for Eli Lilly and Company

Osimertinib (Tagrisso) — drug safety model for AstraZeneca

Pembrolizumab (Keytruda) — drug safety model for Merck & Co.

Secukinumab (Cosentyx) — drug safety model for Novartis

Semaglutide (Ozempic/Wegovy/Rybelsus) — drug safety model for Novo Nordisk

Tirzepatide (Mounjaro/Zepbound) — drug safety model for Eli Lilly and Company

Upadacitinib (Rinvoq) — drug safety model for AbbVie

General-purpose education engine: primitive decomposition, Bayesian mastery, spaced repetition

Unified knowledge daemon — persistent memory with semantic search and temporal decay

Derive macro for nexcore-error: #[derive(Error)] replacement for thiserror

Ghost Mode — privacy-by-design pseudonymization, redaction audit, and PII leak detection for NexVigilant

Grammar algorithms for state functions — experimental Chomsky-Lex Primitiva laboratory

Incident memory and response playbooks for the Homeostasis Machine

Storm detection and prevention for the Homeostasis Machine

KSB assessment integrity via AI text detection — statistical fingerprints aggregated through chemistry primitives with Bloom-level threshold adaptation

Jeopardy!-inspired algorithm R&D investment optimizer using game theory primitives

KSB (Knowledge-Skills-Behaviors) module for NexVigilant Core with 628 PV articles

Knowledge compression, compilation, and query engine for structured knowledge packs

MCP server exposing NexVigilant Core APIs to Claude Code

MCP server hot-reload proxy — auto-restarts child on binary change

Model checking algorithms for CTL/LTL verification of state machines

NexCore OS networking subsystem — connection management, DNS, firewall, routing, monitoring

NotebookLM integration for NexVigilant — notebook library, session management, and browser-automated research queries

Bayesian event prediction engine — learns transition probabilities from event sequences, predicts next events, and self-tracks accuracy

Multi-agent lifecycle, registry, consensus, work queue, and status server for NexVigilant Core

ORGANIZE algorithm — 8-step file organization pipeline grounded to T1 primitives (∃ κ μ → ∂ Σ ∅ ς)

Pharmaceutical company model for AbbVie Inc. — products, pipeline, safety profiles

Pharmaceutical company model for AstraZeneca plc — products, pipeline, safety profiles

Pharmaceutical company model for Bristol-Myers Squibb — products, pipeline, safety profiles

Pharmaceutical company model for GSK plc — products, pipeline, safety profiles

Pharmaceutical company model for Johnson & Johnson / Janssen — products, pipeline, safety profiles

Pharmaceutical company model for Eli Lilly — products, pipeline, safety profiles

Pharmaceutical company model for Merck & Co. — products, pipeline, safety profiles

Pharmaceutical company model for Novartis — products, pipeline, safety profiles

Pharmaceutical company model for Novo Nordisk — products, pipeline, safety profiles

Pharmaceutical company model for Pfizer — products, pipeline, safety profiles

Predictive pharmaceutical R&D taxonomy: 24 T2-P primitives, 14 T2-C composites, 8 T3 domain concepts, Chomsky grammar classification, and cross-domain transfer confidence.

Pharmaceutical company model for Roche — products, pipeline, safety profiles

Pharmaceutical company model for Takeda Pharmaceutical — products, pipeline, safety profiles

WHO-grounded pharmacovigilance taxonomy: 22 T2-P primitives, 20 T2-C composites, 104 T3 domain concepts across detection/assessment/understanding/prevention, Chomsky grammar classification, and cross-domain transfer confidence.

PHAROS — Pharmacovigilance Autonomous Reconnaissance and Observation System. Continuous signal surveillance pipeline.

Automated primitive extraction with CLI, MCP, and hook integration

POSIX pseudo-terminal allocation for NexVigilant terminal sessions

Book publishing pipeline — DOCX to EPUB 3.0 and Kindle-compliant ebooks

Pharmacovigilance intelligence graph — Company x Drug x Disease composition with competitive analysis

Causal reasoning engine — DAG construction, inference, counterfactual testing

SQLite registry for Claude Code skills, agents, metrics, and KPIs

NexVigilant Browser - 100% Rust rendering engine

Retrocasting engine: links FAERS safety signals to molecular structures for pre-market safety prediction

Pure-Rust SSH brute-force protection daemon — a fail2ban replacement

Process-level network signal container — default-deny fence grounded in signal theory

PV signal detection pipeline: ingest, normalize, detect, threshold, store, alert, report, stats, orchestrate

Skill Compiler - compose 2+ skills into a single compound skill binary

SOP-Anatomy-Code triple mapping: 18 governance sections through biological anatomy to software code structures. I.R.O.N.M.A.N. reactor and Capability Transfer Protocol.

Pre-translation structural expectation generator for NMD pipeline surveillance

DNA chemistry analysis pipeline: nucleotide encoding, FFT spectral analysis, nearest-neighbor thermodynamics, 3D projection, resonance mapping, mutation stability, k-means clustering, and Theory of Vigilance safety margin computation.

NexVigilant Station — PV tool resolution gate with confidence-scored config discovery

Generic stdio proxy with hot-reload — protocol-agnostic child process management

Stoichiometric engine for balanced primitive equations — the cargo container for the 15 Lex Primitiva

Autonomous primitive synthesis engine — Level 5 Evolution tool

Core telemetry aggregation and source monitoring for NexVigilant Core

Grounded Theory of Vigilance primitives

Curry-Howard proof verification for Theory of Vigilance - Theorems as Types, Proofs as Programs

Deterministic text transformation engine: segment, annotate, map concepts across domains, compile transformation plans

Universal experimentation framework derived from FDA clinical trial methodology

STEM visualization engine — SVG diagrams for taxonomy, type composition, confidence propagation, and DAG topology

NexCore watch core — pure computation for signal detection, Guardian status, and P0-P5 alerts

Foundation binary word algorithms: typed newtypes (Word8-Word64) with composable trait algebra grounded to State (ς)

Prima - A primitive-first programming language grounded in Lex Primitiva

Prima-to-MCP compiler - expose Prima functions as MCP tools

MCP server that executes Prima functions as tools

Universal Concept Translator: Prima source -> T1 primitives -> Execution

Innovation exploration for NexVigilant Core primitive ecosystem — new T2-C types, cross-domain bridges, and combination space fill

Research-synthesized PVOS expansion: 17 primitive-grounded types across location, frequency, bridges, gaps, and exploratory modules

Unified skill crate: core types, loader, transfer confidence, primitive extraction

STEM: Science, Technology, Engineering, Mathematics as Rust traits

Derive macros for STEM crate T2-P newtypes

Shared macro utilities for STEM derive macros — syn/quote/proc-macro2 helpers

Physics primitives: conservation, forces, waves, scaling

Topological Data Analysis (TDA) for pharmacovigilance signal detection

PRPaaS tenant lifecycle — provisioning, tiers, teams, feature gating

BERT language model implementation using the Burn deep learning framework

Borrow Miner — PV signal detection educational game logic

MCP server for full-access .claude filesystem operations with automatic backups

MCP server for active tapping into Claude's knowledge management system and anatomical tools